Publicaties

Binnen de onderzoeksgroep van het ErasMS worden regelmatig bevindingen gepubliceerd in wetenschappelijke tijdschriften. Ook worden voordrachten gehouden over onderzoeksbevindingen bijvoorbeeld (internationale) congressen

PUBLICATIES 2025
1.Blok KM, Klein Kranenbarg RAM, Ananth K, Engelenburg HJ, van en Bosch A, Giannini LAA, de Beukelaar J, Selaar H, Huitinga I, Green A, Wokke B, Abdelhak A, Smolders J. Multifaceted biomarkers suggest a similar profile of CNS pathology in relapsing and progressive MS. European Journal of Neurology 2025;32(2):e70052. https://onlinelibrary.wiley.com/doi/10.1111/ene.70052
2.Buijze M , Ahmad H, Loudon S, van den Berg R, Wokke B, Smets I. De oogzenuw als vijfde locatie in de 2024 McDonald-criteria voor multiple sclerose. TIJDSCHR NEUROL NEUROCHIR 2025;126(4):131-41. https://www.tnnonline.nl/journal-article/de-oogzenuw-als-vijfde-locatie-in-de-2024-mcdonald-criteria-voor-multiple-sclerose/
3.Chen JQ, McNamara NB, Engelenburg HJ, Jongejan A, Wever DD, Hopman K, van Rixel E, Nijhuis PJH, de Winter F, Moerland PB, Smolders J, Verhaagen J, Hamann J, Huitinga I. Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis. Brain 2025;148(6):2201-2217. https://academic.oup.com/brain/article/148/6/2201/7932175
4.Chen JQ, Wever D, McNamara N, Bourik M, Smolders J, Hamann J, Huitinga I. Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis. Frontiers in Immunology 2025;15:1522381. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1522381/full
5.Coerver EME, Fung WH, de Beukelaar J, Bouvy WH, Canta LR, Gerlach OHH, Hoitsma E, Hoogervorst ELJ, de Jong BA, Kalkers NF, van Kempen ZLE, L?venich H, van Munster CEP, van Oosten BW, Smolders J, Vennegoor A, Zeinstra EMPE, Barrantes-Cepas M, Kooij G, Schoonheim MM, Lissenberg-Witte BI, Teunissen CE, Moraal B, Barkhof F, Uitdehaag BMJ, Mostert J, Killestein J, Strijbis EMM. Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial. JAMA Neurol. 2025;82(2):123-131. https://jamanetwork.com/journals/jamaneurology/fullarticle/2827731
6.Engelenburg HJ, van den Bosch AMR, Chen JQA, Hsiao CC, Melief MJ, Harroud A, Huitinga I, Hamann J, Smolders J. Multiple sclerosis severity variant in DYSF-ZNF638 locus associates with neuronal loss and inflammation. iScience. 2025;28(5):112430. https://www.cell.com/iscience/fulltext/S2589-0042(25)00691-1
7.Fung WH, Wessels MHJ, Coerver EME, de Beukelaar J, Bouvy WH, Canta LR, Gerlach OHH, Hoitsma E, Hoogervorst ELJ, de Jong BA, Kalkers NF, van Kempen ZLE, L?venich H, van Munster CEP, van Oosten BW, Smolders J, Vennegoor A, Zeinstra EMPE, Barrantes-Cepas M, Kooij G, Schoonheim MM, Lissenberg-Witte BI, Moraal B, Barkhof F, Uitdehaag BMJ, Mostert J, Teunissen CE, Killestein J, Strijbis EMM. Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS). J Neurol. 2025;272(8):530. https://link.springer.com/article/10.1007/s00415-025-13231-9
8.Gelissen LMY, Toorop AA, Schipper PM, Hoitsma E, Zeinstra EMPE, van Rooij LC, van Munster CEP, Vennegoor A, Mostert J, Wokke B, Kalkers NF, Hoogervorst ELJ, van Eijk J, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige LGF, Kloosterziel ME, Arnoldus EPJ, Bouvy WH, Strijbis EM, Oosten BV, De Jong BA, Uitdehaag BMJ, Lissenberg-Witte BI, Loeff FC, Rispens T, Killestein J, van Kempen ZLE. Low natalizumab trough concentrations are associated with reduced seroconversion of the John Cunningham virus in natalizumab-treated patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2025:jnnp-2024-335761. https://jnnp.bmj.com/content/early/2025/03/25/jnnp-2024-335761.long
9.Hsiao CC, Engelenburg HJ, Rip J, Wierenga-Wolf AF, van Puijfelik F, van Luijn MM, Huitinga I, Hamann J, Smolders J. Acquisition of residency programs by T cells entering the human brain. Cell Rep. 2025;44(7):115960. https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00731-4
10.Klotz L, Smolders J, Lehto J, Matilainen M, L?tje L, Buchholz L, Albrecht S, Walter C, Varghese J, Wiendl H, Nylund M, Thomas C, Gardberg M, van den Bosch AMR, Airas L, Huitinga I, Kuhlmann T. Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis. Nat Med. 2025;31(6):2016-2026. https://www.nature.com/articles/s41591-025-03625-7
11.Milano C, Saylam E, Papi C, Marmolejo L, Sankovic A, Reinecke R, Kerstens J, Pizzanelli C, Simabukuro MM, Benaiteau M, Joubert B, Gastaldi M, Dutra LA, Leypoldt F, Jansen M, Kawachi I, Akiyama H, Boy N, Bozzetti S, Christensen PB, Businaro P, Dinoto A, Friedman-Korn T, Fujiwara U, Fukumoto T, Fuse K, Hooshmand SI, Hurst L, Iorio R, Korn-Lubetzki I, Rodrigues AFL, Mariotto S, Michael J, Morimoto Y, Neuteboom RF, Piquet AL, Rossetti AO, Rumpler-Kreiner S, Santoro JD, Schwendinger F, Shen B, Syrbe S, Troger J, Wagner I, Bien CG, Martinez-Hernandez E, Armangue T, H?ftberger R, Iizuka T, Titulaer MJ, Honnorat J, Graus F, Dalmau JO, Maga?a S, Spatola M. Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2025 Sep;12(5):e200453. https://www.neurology.org/doi/10.1212/NXI.0000000000200453
12.de Mol CL, Lamballais S, Muetzel R, Duijts L, Smolders J, White T, Neuteboom RF. Environmental multiple sclerosis (MS) risk factors, genetic MS risk, and brain development in a general paediatric population. J Neurol Neurosurg Psychiatry. 2025;96(7):679-685. https://jnnp.bmj.com/content/96/7/679.long
13.Molenaar S, Scherbeijn S, Bruijstens A, Buijze MSJ, Smolders J, Geurts van Kessel C, Neuteboom RF; Dutch study group for paediatric multiple sclerosis and acute disseminated encephalomyelitis. Strong association with remote EBV infection in children with MS as opposed to other acquired demyelinating disorders. J Neurol Neurosurg Psychiatry. 2025:jnnp-2024-335689. https://jnnp.bmj.com/content/early/2025/03/18/jnnp-2024-335689.long
14.Muraro PA, Mariottini A, Greco R, Burman J, Iacobaeus E, Inglese M, Snowden JA, Alexander T, Amato MP, B? L, Boffa G, Ciccarelli O, Cohen JA, Derfuss T, Farge D, Freedman MS, Gaughan M, Heesen C, Kazmi M, Kirzigov K, Ljungman P, Mancardi G, Martin R, Mehra V, Moiola L, Saccardi R, Tintor? M, Stankoff B, Sharrack B; Attendees of the ECTRIMS Focused Workshop on HSCT. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder – recommendations from ECTRIMS and the EBMT. Nature Reviews in Neurology 2025;21(3):140-158. https://www.nature.com/articles/s41582-024-01050-x
15.Pignata A, Frieser D, Gonzalez-Fierro C, Hsiao CC, Engelenburg HJ, Alis M, Fijalkow I, Cazaentre V, Nozeran L, Miranda-Capet R, Dufourd E, Vermeulen T, A?da A, Le Coz C, Van Gisbergen K, Blanchard N, Hamann J, Smolders J, Liblau RS, Masson F. Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice. Sci Transl Med. 2025;17(808):eadp8109. https://www.science.org/doi/10.1126/scitranslmed.adp8109
16.Quaak MSW, Buijze MSJ, Verhoeven VJM, Vermont C, Buddingh EP, Heredia M, Samsom JN, Titulaer MJ, van Rossum AMC, Kamphuis S, Neuteboom RF. Management of Autoimmune Encephalitis in a 7-Year-Old Child With CTLA-4 Haploinsufficiency and AMPA Receptor Antibodies: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2025;12(2):e200381. https://www.neurology.org/doi/10.1212/NXI.0000000000200381
17.Spoor JKH, Hollestelle RVA, Birkenhager TK, De Wit MY, Haitsma IK, Mathijssen IMJ, van Veelen MC, Kamp MA, Pluijms E, Klimek M, Neuteboom R, Maissan I, Dibu? M. Raised Intracranial Pressure in Seizures Induced by Electroconvulsive Therapy. Eur J Neurol. 2025;32(4):e70149. https://onlinelibrary.wiley.com/doi/10.1111/ene.70149
18.van Steenhoven RW, Salih S, de Vries JM, Smets I, Verdijk RM, Gardeniers M, Kerstens J, Brenner J, Crijnen YS, Geurts M, Bromberg JEC, GeurtsvanKessel CH, Sillevis Smitt PAE, Balvers RK, Titulaer MJ. Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real-world cohort study. Ann Clin Transl Neurol. 2025;12(4):792-804. https://onlinelibrary.wiley.com/doi/10.1002/acn3.70000

 

PUBLICATIES 2024
1. de Boer A, van den Bosch AMR, Mekkes NJ, Fransen NL, Dagkesamanskaia E, Hoekstra E, Hamann J, Smolders J, Huitinga I, Holtman IR. Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions. Acta Neuropathologica 2024;147(1):90. https://link.springer.com/article/10.1007/s00401-024-02742-w
2. Bogers L, Rip J, Rijvers L, van Langelaar J, Koetzier SC, Kuiper KL, Meerdink V, Wierenga-Wolf AF, Melief MJ, Marques AM, Smolders J, van Luijn MM. Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis. J Autoimmun 2024;148:103279. https://www.sciencedirect.com/science/article/pii/S0896841124001136?via%3Dihub
3. Brenner J, Ruhe CJ, Kulderij I, Bastiaansen AEM, Crijnen YS, Kret CN, Verkoelen JCP, Tolido AAG, Thomassen B, Kersten LP, de Bruijn MAAM, Olijslagers SHC, Mandarakas MR, Kerstens J, van Steenhoven RW, de Vries JM, Veenbergen S, Schreurs MWJ, Neuteboom RF, Sillevis Smitt PAE, van den Berg E, Titulaer MJ. Long-Term Cognitive, Functional, and Patient-Reported Outcomes in Patients With Anti-NMDAR Encephalitis. Neurology. 2024 Dec 24;103(12):e210109. https://www.neurology.org/doi/10.1212/WNL.0000000000210109?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
4. De Bruijn M, Smolders J, Wokke B. Neuromyelitis optica spectrum ziekte en MOG geassocieerde ziekte. Nervus 2024;2:36-44. https://prelum.nl/nervus/
5. Coerver EME, Fung WH, de Beukelaar J, Bouvy WH, Canta LR, Gerlach OHH, Hoitsma E, Hoogervorst ELJ, de Jong BA, Kalkers NF, van Kempen ZLE, Lövenich H, van Munster CEP, van Oosten BW, Smolders J, Vennegoor A, Zeinstra EMPE, Barrantes-Cepas M, Kooij G, Schoonheim MM, Lissenberg-Witte BI, Teunissen CE, Moraal B, Barkhof F, Uitdehaag BMJ, Mostert J, Killestein J, Strijbis EMM. Discontinuation of first-line disease-modifying therapy in stable multiple sclerosis(DOT-MS): results of a randomized controlled trial. JAMA Neurology 2024 in press https://jamanetwork.com/journals/jamaneurology/fullarticle/2827731
6. Coerver E, Schoof L, Hogenboom L, Wessels M, van Ruyven P, van Samkar A, Mostert J, van Kempen Z, van Oosten BW, Wokke BH, Tallantyre E, Myhr KM, Torkildsen O, Killestein J, Smets I, Strijbis E. The recurrence of disease activity after ocrelizumab discontinuation in multiple sclerosis. Mult Scler Relat Disord. 2024;91:105900. https://www.sciencedirect.com/science/article/pii/S2211034824004760?via%3Dihub
7. Corsten CEA, Wokke BHA, Smolders J. Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size. Brain 2024;147(10):e64-e65. https://academic.oup.com/brain/article/147/10/e64/7714814?login=true
8. van den Bosch AMR, van der Poel M, Fransen NL, Vincenten MCJ, Bobeldijk AM, Jongejan A, Engelenburg HJ, Moerland PD, Smolders J, Huitinga I, Hamann J. Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation. Nat Commun. 2024 Feb 23;15(1):1667. doi: 10.1038/s41467-024-46068-3. https://www.nature.com/articles/s41467-024-46068-3
9. van den Bosch AMR, Wever D, Schonewille P, Schuller SL, Smolders J, Hamann J, Huitinga I. Cortical CD200–CD200R and CD47–SIRPα expression is associated with multiple sclerosis pathology. Brain communications. 2024;6(4):fcae264. https://academic.oup.com/braincomms/article/6/4/fcae264/7729173?login=true
10. Ghezzi A, Neuteboom RF. Correction: Neurofilament Light Chain in Adult and Pediatric Multiple Sclerosis: A Promising Biomarker to Better Characterize Disease Activity and Personalize MS Treatment. Neurol Ther. 2024 Jun;13(3):931. https://link.springer.com/article/10.1007/s40120-024-00598-6
11. ‘t Hart BA, van Luijn MM. EBV infection drives MS pathology: No. Mult Scler 2024 Apr;30(4-5):485-487. https://journals.sagepub.com/doi/full/10.1177/13524585241235833?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
12. Hoeks C, Puijfelik FV, Koetzier SC, Rip J, Corsten CEA, Wierenga-Wolf AF, Melief MJ, Stinissen P, Smolders J, Hellings N, Broux B, van Luijn MM. Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4+ T cells with brain-homing capacity. Eur J Immunol. 2024 Feb;54(2):e2350544. https://onlinelibrary.wiley.com/doi/10.1002/eji.202350544
13. Ingelfinger F, Kuiper KL, Ulutekin C, Rindlisbacher L, Mundt S, Gerdes LA, Smolders J, van Luijn MM, Becher B. Twin Study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis. Med 2024;5(4):368-373.e3. https://www.sciencedirect.com/science/article/pii/S2666634024000850?via%3Dihub
14. Kerstens J, Schreurs MWJ, de Vries JM, Neuteboom RF, Brenner J, Crijnen YS, van Steenhoven RW, de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH, Bastiaansen AEM, Vermeiren MR, Damoiseaux JGMC, Otten HG, Frijns CJM, Meek B, Platteel ACM, van de Mortel A, Delnooz CCS, Broeren MAC, Verbeek MM, Hoff EI, Boukhrissi S, Franken SC, Nagtzaam MMP, Paunovic M, Veenbergen S, Sillevis Smitt PAE, Titulaer MJ. Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance. Neurol Neuroimmunol Neuroinflamm 2024 Nov;11(6):e200318. https://www.neurology.org/doi/10.1212/NXI.0000000000200318?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
15. Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro JD, Narula S, Brenton JN, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas JI, de Seze J, Tenembaum S, Stone RT, Casez O, Carra-Dallière C, Neuteboom RF, Ahsan N, Arroyo HA, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich DS, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo CJ, Kantarci O, Shapiro ED, Okuda DT, Pelletier D; Observatoire Francophone de la Sclérose en Plaques (OFSEP), Société Francophone de la Sclérose en Plaques (SFSEP), Radiologically Isolated Syndrome Consortium (RISC), and the Pediatric Radiologically Isolated Syndrome Consortium (PARIS). The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. J Neurol. 2024 Jul;271(7):4019-4027. https://link.springer.com/article/10.1007/s00415-024-12289-1
16. de Mol CL, Lamballais S, Muetzel R, Duijts L, Smolders J, White T, Neuteboom RF. Environmental MS risk factors, polygenic MS risk and brain development in the general pediatric population. Journal Neurology Neurosurgery Psychiatry 2024 In press. https://jnnp.bmj.com/content/early/2024/11/22/jnnp-2024-335053.long
17. Montalban X, Vermersch P, Arnold DL, Bar-Or A, Cree BAC, Cross AH, Kubala Havrdova E, Kappos L, Stuve O, Wiendl H, Wolinsky JS, Dahlke F, Le Bolay C, Shen Loo L, Gopalakrishnan S, Hyvert Y, Javor A, Guehring H, Tenenbaum N, Tomic D; evolutionRMS investigators. Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials. Lancet Neurol. 2024 Nov;23(11):1119-1132. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00328-4/fulltext
18. El Naggar I, Cleaveland R, Panzer A, Molenaar S, Giorgi L, Wendel EM, Bertolini A, Karenfort M, Thiels C, Libá Z, Baumann M, Leiz S, Della Marina A, Hengstler JG, Deiva K, Neuteboom R, Reindl M, Rostásy K; BIOMARKER study group. Long-term follow-up MR imaging in children with transverse myelitis. Mult Scler Relat Disord. 2024 Dec;92:105926. https://www.sciencedirect.com/science/article/pii/S2211034824005029?via%3Dihub
19. Neuteboom RF. The importance of long term follow-up in children with acquired demyelinating syndromes. Eur J Paediatr Neurol. 2024 Sep;52:A2. https://www.sciencedirect.com/science/article/pii/S1090379824001338?via%3Dihub
20. Neuteboom RF. Testing for MOG-IgG in CSF: Relevant or not? Eur J Paediatr Neurol. 2024 Jul;51:A1. https://www.sciencedirect.com/science/article/pii/S1090379824001016?via%3Dihub
21. Olijslagers SHC , Lemmens CMC, Lycklama à Nijeholt GJ, Wokke B. Diagnostiek bij myelopathie. Tijdschr Neurol Neurochir 2024;125(7):312-20. https://www.tnnonline.nl/journal-article/diagnostiek-bij-myelopathie/
22. van Puijfelik F, Blok KM, Klein Kranenbarg RAM, Rip J, de Beukelaar J, Wierenga-Wolf AF, Wokke B, van Luijn MM, Smolders J. Ocrelizumab associates with reduced cerebrospinal fluid B and CD20dim CD4+ T cells in primary progressive multiple sclerosis. Brain Commun. 2024 Jan 29;6(1):fcae021. https://academic.oup.com/braincomms/article/6/1/fcae021/7591528
23. Quaak MSW, Buijze MSJS, Verhoeven VJM, Vermont C, Buddingh EP, Heredia M, Samsom JN, Titulaer MJ, van Rossum AM, Kamphuis S, Neuteboom RF. Management of Autoimmune Encephalitis in a 7-Year-Old Child With CTLA-4 Haploinsufficiency and AMPA Receptor Antibodies: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2024 Jul;11(4):e200254. https://www.neurology.org/doi/10.1212/NXI.0000000000200254?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
24. Smets I, Versteegh M, Huygens S, Wokke B, Smolders J. Benefits of early highly-effective versus escalation treatment strategies in relapsing multiple sclerosis estimated using a treatment-sequence model. Multiple Sclerosis Journal 2024;30(8):1016-25. https://journals.sagepub.com/doi/full/10.1177/13524585241258692?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
25. Smets I, van Steenhoven RW, Veenbergen S, de Vries JM, Gardeniers M, Titulaer MJ. GFAP-astrocytopathie: een nieuwe, behandelbare vorm van myelitis of meningo-encefalitis. Tijdschr Neurol Neurochir 2024;125(5):188–95. https://www.tnnonline.nl/journal-article/gfap-astrocytopathie-een-nieuwe-behandelbare-vorm-van-myelitis-of-meningo-encefalitis/
26. Smolders J, Hamann J, Huitinga I. Modification of T- and B-cell-associated immuno-pathologic mechanisms in multiple sclerosis by disease modifying therapies: Achievements and opportunities. Handb Clin Neurol. 2024;202:7-21. https://www.sciencedirect.com/science/article/abs/pii/B978032390242700016X?via%3Dihub
27. Titulaer MJ, Neuteboom RF. Seronegative autoimmune encephalitis in children: What’s in a name? Dev Med Child Neurol. 2024 Oct;66(10):1267-1268. https://onlinelibrary.wiley.com/doi/10.1111/dmcn.15911
28. Toorop AA, Wessels MH, Boonkamp L, Gelissen LM, Hoitsma E, Zeinstra EM, van Rooij LC, van Munster CE, Vennegoor A, Mostert JP, Wokke BH, Kalkers NF, Hoogervorst EL, van Eijk JJ, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige L, Kloosterziel ME, Arnoldus EP, van Dijk GW, Bouvy WH, Strijbis EM, van Oosten BW, de Jong BA, Uitdehaag BM, Rispens T, Killestein J, van Kempen ZL, Teunissen CE. Serum neurofilament light and glial fibrillary acidic protein levels are not associated with wearing-off symptoms in natalizumab-treated multiple sclerosis patients. Mult Scler 2024;30(13):1683-1688. https://journals.sagepub.com/doi/full/10.1177/13524585241293940?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
29. Toorop AA, Wessels MHJ, Gelissen LMY, Hoitsma E, Zeinstra EMPE, van Rooij LC, van Munster CEP, Vennegoor A, Mostert JP, Wokke BHA, Kalkers NF, Hoogervorst ELJ, van Eijk JJJ, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige LGF, Kloosterziel ME, Arnoldus EPJ, van Dijk GW, Bouvy WH, Strijbis EMM, van Oosten BW, de Jong BA, Lissenberg-Witte BI, Rispens T, Uitdehaag BMJ, Killestein J, van Kempen ZLE. Toorop AA, Wessels MHJ, Gelissen LMY, Hoitsma E, Zeinstra EMPE, van Rooij LC, van Munster CEP, Vennegoor A, Mostert JP, Wokke BHA, Kalkers NF, Hoogervorst ELJ, van Eijk JJJ, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige LGF, Kloosterziel ME, Arnoldus EPJ, van Dijk GW, Bouvy WH, Strijbis EMM, van Oosten BW, de Jong BA, Lissenberg-Witte BI, Rispens T, Uitdehaag BMJ, Killestein J, van Kempen ZLE. J Neurol Sci. 2024;462:123102. https://www.sciencedirect.com/science/article/pii/S0022510X24002375?via%3Dihub
30. Wijburg MT, Mostert JP, Killestein J, Michels CTJ , Molag ML, Smolders J, de Jong BA. Addendum en revisioe landelijke richtlijn multiple sclerose; een levende richtlijn. Tijdschr Neurol Neurochir 2024;125(5):216–20. https://www.tnnonline.nl/journal-article/addendum-en-revisie-landelijke-richtlijn-multiple-sclerose-een-levende-richtlijn/
PUBLICATIES 2023
1. Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol. 2023 Jan 24:S1474-4422(22)00431-8. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00431-8/fulltext.
2. Blok KM, van Rosmalen J, Tebayna N, Smolders J, Wokke B, de Beukelaar J. Disease activity in primary progressive multiple sclerosis: a systematic review and meta-analysis. Front Neurol. 2023 Nov 6;14:1277477. doi: 10.3389/fneur.2023.1277477. eCollection 2023. https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1277477/full
3. Blok KM, Smolders J, van Rosmalen J, Martins Jarnalo CO, Wokke B, de Beukelaar J. Real-world challenges in the diagnosis of primary progressive multiple sclerosis. Eur J Neurol. 2023 Dec;30(12):3799-3808. doi: 10.1111/ene.16042. Epub 2023 Sep 15. https://onlinelibrary.wiley.com/doi/10.1111/ene.16042
4. Bogers L, Engelenburg HJ, Janssen M, Unger PP, Melief MJ, Wierenga-Wolf AF, Hsiao CC, Mason MRJ, Hamann J, van Langelaar J, Smolders J, van Luijn MM. Selective emergence of antibody-secreting cells in the multiple sclerosis brain. eBioMedicine 2023;89:104465. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00030-0/fulltext.
5. Bogers L, Kuiper KL, Smolders J, Rip J, van Luijn MM. Epstein-Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases. Immunol Lett. 2023 Sep;261:66-74. doi: 10.1016/j.imlet.2023.07.006. https://www.sciencedirect.com/science/article/pii/S0165247823001189?via%3Dihub
6. van den Bosch AMR, Hümmert S, Steyer A, Ruhwedel T, Hamann J, Smolders J, Nave KA, Stadelmann C, Kole MHP, Möbius W, Huitinga I. Ultrastructural Axon-Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation. Ann Neurol. 2023;83:856-870. https://onlinelibrary.wiley.com/doi/10.1002/ana.26585
7. Brenner J, Mariotto S, Bastiaansen AEM, Paunovic M, Ferrari S, Alberti D, de Bruijn MAAM, Crijnen YS, Schreurs MWJ, Neuteboom RF, Damoiseaux JGMC, de Vries JM, Titulaer MJ. Predictive Value of Serum Neurofilament Light Chain Levels in Anti-NMDA Receptor Encephalitis. Neurology. 2023 Apr 4:10.1212/WNL.0000000000207221. https://n.neurology.org/content/early/2023/04/03/WNL.0000000000207221.long
8. Bruijstens AL, Stingl C, Güzel C, Stoop MP, Wong YYM, van Pelt ED, Banwell BL, Bar-Or A, Luider TM, Neuteboom RF; Dutch Pediatric MS and ADEM Study Group; Canadian Pediatric Demyelinating Disease Network. Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood. Mult Scler. 2023 Jan;29(1):52-62. https://journals.sagepub.com/doi/full/10.1177/13524585221125369
9. Corsten CEA, Huygens SA, Versteegh MM, Wokke BHA, Smets I, Smolders J. Benefits of sphingosine-1-phosphate receptor modulators in relapsing MS estimated with a treatment sequence model. Mult Scler Relat Disord. 2023 Dec;80:105100. doi: 10.1016/j.msard.2023.105100. Epub 2023 Oct 22. https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(23)00601-6
10. Ghezzi A, Neuteboom RF. The contribution of neurofilament light chain to better characterize pediatric multiple sclerosis (editorial on: Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial). Mult Scler. 2023 Mar 23;13524585231161148. https://journals.sagepub.com/doi/10.1177/13524585231161148?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
11. Hsiao CC, Engelenburg HJ, Jongejan A, Zhu J, Zhang B, Mingueneau M, Moerland PD, Huitinga I, Smolders J, Hamann J. Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis. iScience. 2022 Dec 9;26(1):105785. https://www.cell.com/iscience/fulltext/S2589-0042(22)02058-2
12. International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium. Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature. 2023 Jul;619(7969):323-331. doi: 10.1038/s41586-023-06250-x. Epub 2023 Jun 28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602210/
13. de Mol CL, van Luijn MM, Kreft KL, Looman KIM, van Zelm MC, White T, Moll HA, Smolders J, Neuteboom RF. Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population. Eur J Neurol. 2023 Feb;30(2):434-442. https://onlinelibrary.wiley.com/doi/10.1111/ene.15582.
14. Neuteboom R. Real world data on treatment of pediatric onset multiple sclerosis. Eur J Paediatr Neurol. 2023 Jul;45:A1. doi: 10.1016/j.ejpn.2023.06.011. Epub 2023 Jun 30. https://linkinghub.elsevier.com/retrieve/pii/S1090-3798(23)00101-0
15. Ombashi S, Tsangaris E, Heeres AG, van Roey V, Neuteboom RF, van Veelen-Vincent MLC, Jansson K, Mathijssen IMJ, Klassen AF, Versnel SL. Quality of life in children suffering from headaches: a systematic literature review. J Headache Pain. 2023 Sep 18;24(1):127. doi: 10.1186/s10194-023-01595-0 https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-023-01595-0
16. Smets I, Wokke B, Smolders J. Should anti-CD20 be used as an immune reconstitution therapy? Mult Scler. 2023 Feb;29(2):308-310. https://journals.sagepub.com/doi/full/10.1177/13524585221109386.
17. Smets I, Versteegh M, Huygens S, Corsten C, Wokke B, Smolders J. Health-economic benefits of anti-CD20 treatments in relapsing multiple sclerosis estimated using a treatment-sequence model. Mult Scler J Exp Transl Clin. 2023 Jul 24;9(3):20552173231189398. doi: 10.1177/20552173231189398 https://journals.sagepub.com/doi/10.1177/20552173231189398
18. Smets I. Presymptomatic MS or radiologically isolated syndrome (RIS) should be actively monitored and treated – NO. Multiple Sclerosis Journal 2023;29(7):795-797. https://journals.sagepub.com/doi/10.1177/13524585231172945
19. Smolders J. NAAR EEN OPTIMALE INZET VAN VEELZIJDIGE ANTI-CD20-THERAPIE BIJ NEUROLOGISCHE ZIEKTEBEELDEN. TIJDSCHR NEUROL NEUROCHIR 2023;124(7):285–6. https://www.tnnonline.nl/journal-article/naar-een-optimale-inzet-van-veelzijdige-anti-cd20-therapie-bij-neurologische-ziektebeelden/
20. Smolders J, Steelman AJ, Inoue M. Editorial: Environmental factors influencing the immune functions during multiple sclerosis. Front Immunol. 2023 Jan 20;14:1141014. https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141014/full.
21. Smolders J, Damoiseaux J. Considerations on vitamin D supplementation in multiple sclerosis, 1 Jan 2023, Vitamins and Minerals in Neurological Disorders. Martin, C. R., Patel, V. B. & Preedy, V. R. (eds.). 1 ed. Elsevier Inc., p. 359-377 19 p. https://www.sciencedirect.com/science/article/abs/pii/B9780323898355000120?via%3Dihub
22. Van Steenhoven RW, de Vries JM, Bruijstens AL, Paunovic M, Nagtzaam MM, Franken SC, Bastiaansen AE, De Bruijn MA, Van Sonderen A, Schreurs MWJ, Gardeniers M, Verdijk RM, Balvers RK, Sillevis Smitt PA, Neuteboom RF, Titulaer MJ. Mimics of Autoimmune Encephalitis: Validation of the 2016 Clinical Autoimmune Encephalitis Criteria. Neurol Neuroimmunol Neuroinflamm. 2023 Aug 15;10(6):e200148. doi: 10.1212/NXI.0000000000200148. Print 2023 Nov. https://www.neurology.org/doi/10.1212/NXI.0000000000200148
23. Toorop AA, van Kempen ZLE, Steenhuis M, Nielsen J, Sinnige LGF, van Dijk G, Roosendaal CM, Arnoldus EPJ, Hoitsma E, Lissenberg-Witte BI, de Jong BA, Oosten BWV, Strijbis EMM, Uitdehaag BMJ, Rispens T, Killestein J; NEXT-MS study group. Decrease of natalizumab drug levels after switching from intravenous to subcutaneous administration in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2023 Jun;94(6):482-486. doi: 10.1136/jnnp-2022-330467. Epub 2023 Jan 13. https://jnnp.bmj.com/content/94/6/482
24. Toorop AA, van Lierop ZY, Gelissen LM, Hoitsma E, Zeinstra EM, van Rooij LC, van Munster CE, Vennegoor A, Mostert JP, Wokke BH, Kalkers NF, Hoogervorst EL, van Eijk JJ, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige L, Kloosterziel ME, Arnoldus EP, van Dijk GW, Bouvy WH, Wessels MH, Boonkamp L, Strijbis EM, van Oosten BW, De Jong BA, Lissenberg-Witte BI, Barkhof F, Moraal B, Teunissen CE, Rispens T, Uitdehaag BM, Killestein J, van Kempen ZL. Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS). J Neurol Neurosurg Psychiatry. 2023 Nov 14:jnnp-2023-332119. doi: 10.1136/jnnp-2023-332119. https://jnnp.bmj.com/content/early/2023/11/13/jnnp-2023-332119
25. Willekens BMP, Kleffner I, Wokke B. Editorial: Epidemiology, diagnosis, prognosis and treatment of rare immune-mediated diseases of the central nervous system. Front Neurol. 2023 Dec 13;14:1342817. doi: 10.3389/fneur.2023.1342817. eCollection 2023 https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1342817/full
PUBLICATIES 2022
1. van den Bosch A, Fransen N, Mason M, Rozemuller AJ, Teunissen C, Smolders J, Huitinga I. Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 3;9(3):e1154. https://nn.neurology.org/content/9/3/e1154.long
2. Bruijstens AL, Molenaar S, Wong YYM, Kraaij R, Neuteboom RF. Gut microbiota analysis in pediatric-onset multiple sclerosis compared to pediatric monophasic demyelinating syndromes and pediatric controls. Eur J Neurol. 2022 Oct 9. doi: 10.1111/ene.15594. Online ahead of print. https://onlinelibrary.wiley.com/doi/full/10.1111/ene.15594
3. Cappelle S, Pareto D, SunaertS, Smets I, Laenen A, Dubois B, Demaerel Ph. 3T1w/FLAIR ratio standardization as a myelin marker in MS patients. Neuroimage Clin. 2022;36:103248. https://www.sciencedirect.com/science/article/pii/S2213158222003138?via%3Dihub
4. Dohrn MF, Rebelo AP, Srivastava S, Cappuccio G, Smigiel R, Malhotra A, Basel D, van de Laar I, Neuteboom RF, Aarts-Tesselaar C, Mahida S, Brunetti-Pierri N, Taft RJ, Züchner S De Novo ATP1A1 Variants in an Early-Onset Complex Neurodevelopmental Syndrome. Neurology. 2022;98(11):440-445. https://n.neurology.org/content/98/11/440.long
5. Helfferich J, de Lange MM, Benschop KS, Jacobs BC, Van Leer-Buter CC, Meijer A, Bakker DP, de Bie E, Braakman HM, Brandsma R, Neuteboom RF, Niks EH, Niermeijer JM, Roelfsema V, Schoenmaker N, Sie LT, Niesters HG, Brouwer OF, Te Wierik MJ. Epidemiology of acute flaccid myelitis in children in the Netherlands, 2014 to 2019. Euro Surveill. 2022 Oct;27(42):2200157. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.42.2200157
6. Koetzier S, van Langelaar J, Melief MJ, wierenga-Wolf AF, Corsten CEA, Blok KM, Hoeks C, Broux B, Wokke B, van Luijn MM, Smolders J. distinct effector programs of brain-homing CD8+ T cells in multiple sclerosis. Cells 2022;11(10):1634. https://www.mdpi.com/2073-4409/11/10/1634
7. Koetzier SC, van Langelaar J, Wierenga-Wolf AF, Melief MJ, Pol K, Musters S, Lubberts E, Dik WA, Smolders J, van Luijn MM. Improving glucocorticoid sensitivity of brain-homing CD4 + T helper cells by steroid hormone crosstalk. Frontiers Immunol 2022;13:893702. https://www.frontiersin.org/articles/10.3389/fimmu.2022.893702/full
8. de Mol CL, Neuteboom RF, Jansen PR, White T. Response: No evidence for association between polygenic risk for multiple sclerosis and MRI phenotypes in approximately 30,000 healthy adult UK Biobank participants. Mult Scler. 2022;28(10):1658-9. https://journals.sagepub.com/doi/10.1177/13524585221079044
9. Rijvers L, van Langelaar J, Bogers L, Melief MJ, Koetzier SC, Blok KM, Wierenga-Wolf AF, de Vries HE, Rip J, Corneth OB, Hendriks RW, Grenningloh R, Boschert U, Smolders J, van Luijn MM. Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib. JCI Insight. 2022 Aug 22;7(16):e160909. https://insight.jci.org/articles/view/160909
10. Smolders J, van Luijn MM, Hsiao CC, Hamann J. T-cell surveillance of the human brain in health and multiple sclerosis. Semin Immunopathol. 2022 Nov;44(6):855-867. https://link.springer.com/article/10.1007/s00281-022-00926-8
11. Smolders J, Hamann J. Programmed Cell Death Protein 1–Positive CD8+ T Cells in Multiple Sclerosis Exhausted Fighters or Peacekeepers. Neurol Neuroimmunol Neuroinflamm. 2022;9(4):e1173. https://nn.neurology.org/content/9/4/e1173.long
12. Tseng LA, Teela L, Janssen MC, Bok LA, Willemsen MAAP, Neuteboom RF, Haverman L, Gospe SM Jr, Coughlin CR, van Karnebeek CDM. Pyridoxine-dependent epilepsy (PDE-ALDH7A1) in adulthood: A Dutch pilot study exploring clinical and patient-reported outcomes. Mol Genet Metab Rep. 2022;31:100853. https://www.sciencedirect.com/science/article/pii/S2214426922000131?via%3Dihub
13. Versteegh MM, Huygens SA, Wokke BHA, Smolders J. Effectiveness and Cost-Effectiveness of 360 Disease-Modifying Treatment Escalation Sequences in Multiple Sclerosis. Value Health. 2022 Jun;25(6):984-991. https://www.sciencedirect.com/science/article/pii/S1098301521031946?via%3Dihub
14. Willekens BMP, Bruijstens AL, Neuteboom R, Smolders J, Wokke BHA. MOGAD: MOG antibody associated disease. Tijdschr neurol neurochi 2022;123(8):354-60. https://www.tnnonline.nl/journal-article/mogad-mog-antistof-gerelateerde-ziekte/

PUBLICATIES 2021
1. Aalbers MW, Groen RJM, Appelman APA, Heersema TDJ, Wokke BHA, Oterdoom DLM. Spinal cord  ischaemia related to disc herniation: case report and a review of the literature. International medical case reports journal. 2021 June;14:429-433
2. de Mol CL, Bruijstens AL, Jansen PR, Dremmen M, Wong Y, van der Lugt A, White T, Neuteboom RF. Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis. Mult Scler. 2021 Jan 22:1352458521989220.
3. Den Dunnen J, Mes L, Hoepel W, Smolders J. Multiple sclerosis: why we should focus on both sides of the antibody. Neural Regeneration Research 2021;16:2422-4.
4. Drop BRH, Zemel D, Wokke BHA, van Oosten BW, Dik S, Martins Jarnalo CO, Westerweel PE, de Beukelaar JWK. Diffuse alveolar hemorrhage as an early complication of alemtuzumab treatment: A case report of a multiple sclerosis patient and an overview of 14 cases. Mult Scler Relat Disord 2021;47:102614.
5. Fransen N, de Jong BA, Heß K, Kuhlmann T, Vincenten MCJ, Hamann J, Huitinga I, Smolders J. Absence of B cells in brainstem and white matter lesions associates with less severe disease and absence of oligoclonal bands in MS. Neurology Neuroimmunology & Neuroinflammation 2021;8:e995.
6. Ghedri A, Hintzen RQ, Wokke BHA, Pruissen DMO; Snelle diagnostiek en behandeling essentieel bij neuromyelitis optica spectrum disorder. Tijdschr neurol neurochir 2020;1221(4):171-5
7. Helfferich J, Bruijstens AL, Wong YYM, Danielle van Pelt E, Boon M, Neuteboom RF; Dutch Study Group for Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis. Prognostic factors for relapse and outcome in pediatric acute transverse myelitis. Brain Dev. 2021;43:626-636.
8. Hsiao CC, Fransen NL, van den Bosch AMR, Brandwijk KIM, Hamann J, Smolders J. White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells. European Journal of Immunology 2021;51:483-6..
9. Hsiao CC, Sankowski R, Prinz M, Smolders J, Huitinga I, Hamann J. GPCRomics of homeostatic and disease-associated human microglia. Frontiers in Immunology 2021, Frontiers in Immunology 2021;12:674189.
10. Janssen M, Rijvers L, Koetzier SC, Wierenga-Wolf AF, Melief MJ, van Langelaar J, Runia TF, de Groot CJM, Neuteboom R, Smolders J, van Luijn MM. Pregnancy-induced effects on memory B-cell development in multiple sclerosis. Scientific Reports 2021;11:12126.
11. Koetzier SC, Neuteboom RF, Wierenga-Wolf AF, Melief MJ, de Mol CL, van Rijswijk A, Dik WA, Broux B, van der Wal R, van den Berg SAA, Smolders J, van Luijn MM. Effector T helper cells are selectively controlled during pregnancy and related to a postpartum relapse in multiple sclerosis. Frontiers in Immunology 2021;12:642038.
12. Mimpen M, Muris AH, Rolf L, Gerlach O, Kuhle J, Hupperts R, Smolders J, Damoiseaux J. Prognostic value of NK cell/ T cell ratios for disease activity in multiple sclerosis. European Journal of Neurology 2021;28:901-9.
13. Mimpen M, Rolf L, Muris AH, Gerlach O, Poelmans G, Hupperts R, Smolders J, Damoiseaux J. NK/T cell ratio’s associate with IL-2 receptor alpha chain expression and shedding in multiple sclerosis. Journal of Neuroimmunology 2021;343:577499.
14. Smolders J, de Beer JJA, Frequin STFM, Harrison K, van Hoeve BJA , Hoitsma E, Hoogervorst ELJ, Killestein J, Lenderink AW, Moraal B, Mostert J, Siepman TAM, Witte DT, de Jong BA. Ziektemodulerende behandeling van mutiple sclerose bij volwassenen: Addendum bij de richtlijn multiple sclerose. Tijdschr Neurol Neurochir 2021;122:17-21.
15. Smolders J, Fransen NL, Huitinga I, Hamann J. Reply: Tissue-resident CD8+ memory T cells in multiple sclerosis. Brain 2021;144:e8.
16. Smolders J, Hiller A, Camu W. Editorial: Vitamin D in Neurological Diseases: From Pathophysiology to Therapy. Front Neurol. 2021 Mar 9;12:614900.
17. Smolders J, van den Ouweland J, Geven C, Prickkers P, Kox M. Vitamin D deficiency in COVID-19: mixing up cause and consequence. Metabolism, 2021;115;154434.
18. Van den Berg R, Broeders M, Wokke BHA, Thiadens AAHJ, Asseldonk JT, Titulaer. Syndorom van SUSAC: visusstoornis, doofheid en encefalopathie. Tijdschr neurol neurochir 2020;121(1):24-30
19. van Langelaar J, Wierenga-Wolf AF, Samijn JPA, Luijks CJM, Siepman TA, van Doorn PA, Bell A, van Zelm MC, Smolders J, van Luijn MM. The association of Epstein-Barr virus infection with CXCR3+ B-cell development in multiple sclerosis: impact of immunotherapies. European Journal of Immunology 2021;51:626-33.
20. de Mol CL, Looman KIM, van Luijn MM, Kreft KL, Jansen PR, van Zelm MC, Smolders J, White TJH, Moll HA, Neuteboom RF.T cell composition and polygenic multiple sclerosis risk: A population-based study in children. Eur J Neurol. 2021 Jul 12. doi: 10.1111/ene.15019.
21. Mimpen M , Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J. Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients. J Neuroimmunol 2021;358:577664.
22. de Mol CL, Neuteboom RF, Jansen PR, White T. White matter microstructural differences in children and genetic risk for multiple sclerosis: A population-based study. Mult Scler 2021, doi: 10.1177/13524585211034826.
23. Nosadini M, Thomas T, Eyre M, Anlar B, Armangue T, Benseler SM, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK, Irani SR, Dalmau J, Lim M, Dale RC. International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis. Neurol Neuroimmunol Neuroinflamm 2021;8(5):e1052.
24. Mimpen M, Rolf L, Poelmans G, van den Ouweland J, Hupperts R, Damoiseaux J, Smolders J. Vitamin D related genetic polymorphisms affect serological response to high-dose vitamin D supplementation in multiple sclerosis. PLoS One. 2021 Dec 2;16(12):e0261097
25. Bastiaansen AEM, de Bruijn MAAM, Schuller SL, Martinez-Hernandez E, Brenner J, Paunovic M, Crijnen YS, Mulder MJHL, Schreurs MWJ, de Graaff E, Smitt PAE, Neuteboom RF, de Vries JM, Titulaer MJ. Anti-NMDAR Encephalitis in the Netherlands, Focusing on Late-Onset Patients and Antibody Test Accuracy. Neurol Neuroimmunol Neuroinflamm. 2021 Dec 22;9(2):e1127.
26. Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M; International NMDAR Antibody Encephalitis Consensus Group, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostásy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK. Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis. JAMA Neurol. 2021 Nov 1;78(11):1333-1344.

PUBLICATIES 2020
1. Armangue T, Capobianco M, de Chalus A, Laetitia G, Deiva K; E.U. paediatric MOG consortium. E.U. paediatric MOG consortium consensus: Part 3 – Biomarkers of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol. 2020 Nov;29:22-31. 
2. Baumann M, Bartels F, Finke C, Adamsbaum C, Hacohen Y, Rostásy K; E.U. paediatric MOG consortium. E.U. paediatric MOG consortium consensus: Part 2 – Neuroimaging features of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol. 2020 Nov;29:14-21.
3. Bruijstens AL, Blok KM, Smolders J, Wokke BH, Neuteboom RF. Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment. Multiple Sclerosis Journal 2020;26:1962-4. 
4. Bruijstens AL, Breu M, Wendel EM, Wassmer E, Lim M, Neuteboom RF, Wickström R; E.U. paediatric MOG consortium. E.U. paediatric MOG consortium consensus: Part 4 – Outcome of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol. 2020 Nov;29:32-40. 
5. Bruijstens AL, Lechner C, Flet-Berliac L, Deiva K, Neuteboom RF, Hemingway C, Wassmer E; E.U. paediatric MOG consortium. E.U. paediatric MOG consortium consensus: Part 1 – Classification of clinical phenotypes of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol. 2020 Nov;29:2-13.
6. Bruijstens AL, Wendel EM, Lechner C, Bartels F, Finke C, Breu M, Flet-Berliac L, de Chalus A, Adamsbaum C, Capobianco M, Laetitia G, Hacohen Y, Hemingway C, Wassmer E, Lim M, Baumann M, Wickström R, Armangue T, Rostasy K, Deiva K, Neuteboom RF. E.U. paediatric MOG consortium consensus: Part 5 – Treatment of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol. 2020 Nov;29:41-53. 
7. Bruijstens AL, Wong YYM, van Pelt DE, van der Linden PJE, Haasnoot GW, Hintzen RQ, Claas FHJ, Neuteboom RF, Wokke BHA. HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population. Neurol Neuroimmunol Neuroinflamm. 2020;7(3):e702. 
8. de Bruijn MAAM, Bruijstens AL, Bastiaansen AEM, van Sonderen A, Schreurs MWJ, Sillevis Smitt PAE, Hintzen RQ, Neuteboom RF, Titulaer MJ; CHANCE Study Group. Pediatric autoimmune encephalitis: Recognition and diagnosis. Neurol Neuroimmunol Neuroinflamm. 2020 Feb 11;7(3):e682.
9. de Mol CL, Jansen PR, Muetzel RL, Knol MJ, Adams HH, Jaddoe VW, Vernooij MW, Hintzen RQ, White TJ, Neuteboom RF. Polygenic Multiple Sclerosis Risk and Population-Based Childhood Brain Imaging. Ann Neurol. 2020 May;87(5):774-787. 
10. de Mol CL, Wong Y, van Pelt ED, Wokke B, Siepman T, Neuteboom RF, Hamann D, Hintzen RQ. The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults. Mult Scler 2020;26:806-814.
11. Doerga PN, Rijken BFM, Bredero-Boelhouwer H, Joosten KFM, Neuteboom RF, Tasker RC, Dremmen MHG, Lequin MH, van Veelen MLC, Mathijssen IMJ. Neurological deficits are present in syndromic craniosynostosis patients with and without tonsillar herniation. Eur J Paediatr Neurol. 2020 Sep;28:120-125. 
12. Fransen N, Hsiao CC, van der Poel M, Engelenburg HJ, Verdaasdonk K, Vincenten MCJ, Remmerswaal EBM, Kuhlmann T, Mason MRJ, Hamann J, Smolders J, Huitinga I. Tissue resident memory T cells invade the brain parenchyma in chronic multiple sclerosis white matter lesions. Brain 2020;143:1714-30.
13. Fritz D, Timmermans WMC, van Laar JAM, van Hagen PM, Siepman TAM, van de Beek D, Brouwer MC. Infliximab treatment in pathology-confirmed neurosarcoidosis. Neurol Neuroimmunol Neuroinflamm. 2020;7:e847.
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15. Janssen M, Bruijstens AL, van Langelaar J, Wong Y, Wierenga-Wolf AF, Melief MJ, Rijvers L, van Pelt ED, Smolders J, Wokke BH, van Luijn MM. Naive B cells in neuromyelitis optica spectrum disorders: impact of steroid use and relapses. Brain Comm 2020;2:fcaa197. 
16. Koetzier SC, van Langelaar J, Blok KM, van den Bosch TPP, Wierenga-Wolf AF, Melief MJ, Pol K, Siepman TA, Verjans GMGM, Smolders J, Lubberts E, de Vries HE, van Luijn MM. Brain-homing CD4+ T cells display glucocorticoid-resistant features in multiple sclerosis. Neurology Neuroimmunology & Neuroinflammation 2020;7:e894. 
17. Mescheriakova JY, van Nierop GP, van der Eijk AA, Kreft KL, Hintzen RQ. EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution. Neurol Neuroimmunol Neuroinflamm. 2020 Aug 13;7(6):e872.
18. Mimpen M, Smolders J, Hupperts R, Damoiseaux J. Natural Killer Cells in Multiple Sclerosis, a review. Immunology Letters 2020;222:1-11. 
19. Muñoz-Lopetegi A, de Bruijn MAAM, Boukhrissi S, Bastiaansen AEM, Nagtzaam MMP, Hulsenboom ESP, Boon AJW, Neuteboom RF, de Vries JM, Sillevis Smitt PAE, Schreurs MWJ, Titulaer MJ. Neurologic syndromes related to anti-GAD65: Clinical and serologic response to treatment. Neurol Neuroimmunol Neuroinflamm. 2020 Mar 2;7(3):e696.
20. Neuteboom RF, Deiva K, Rostasy K. Editorial on EJPN focus section on E.U. paediatric MOG consortium consensus statements. Eur J Paediatr Neurol. 2020 Nov;29:1.
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22. Pak N, Selehnia A, Hunfeld MAW, Lequin MH, Neuteboom RF, de Vries ACH, Kroon AA, Dremmen MHG. Atypical neuroimaging characteristics of hemophagocytic lymphohistiocytosis in infants: a case series of hemorrhagic brain lesions in the deep grey matter. Neuroradiology. 2021 Feb;63(2):285-288. 
23. Paolilo RB, Deiva K, Neuteboom R, Rostásy K, Lim M. Acute Disseminated Encephalomyelitis: Current Perspectives. Children (Basel). 2020 Nov 3;7(11):210. 
24. Paolilo RB, Hacohen Y, Yazbeck E, Armangue T, Bruijstens A, Lechner C, Apostolos-Pereira SL, Martynenko Y, Breu M, de Medeiros Rimkus C, Wassmer E, Baumann M, Papetti L, Capobianco M, Kornek B, Rostásy K, da Paz JA, Ciccarelli O, Lim M, Saiz A, Neuteboom R, Marignier R, Hemingway C, Sato DK, Deiva K. Treatment and outcome of aquaporin-4 antibody-positive NMOSD: A multinational pediatric study. Neurol Neuroimmunol Neuroinflamm. 2020 Jul 30;7(5):e837.
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26. Smolders J, Fransen NL, Hsiao CC, Hamann J, Huitinga I. Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis. Expert Reviews in Neurotherapeutics, 2020;20:835-48. 
27. Van Langelaar J, Rijvers L, Smolders J, van Luijn MM. B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers. Frontiers in Immunology 2020;11:760. 
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